Sunday 25th February 2024
Durbar Marg, Kathmandu

Vitamin A acid can reduce wrinkles and improve skin roughness, increase in dermal thickness and stimulate collagen deposition, have anti-aging effects on the skin. One study showed that the efficacy of 0.025%vitamin A acid is the same as the efficacy of 0.05% or 0.1% vitamin A acid, also can reduce the irritation of the skin. The study also found that continuous use of vitamin A acid a year, its role will continue to improve. The most common side effects of topical vitamin A acid is irritating to the skin, it is often sold as a prescription drug.

Vitamin A acid appeared in many occasions in medicine, such as tretinoin, isotretinoin, acitretin and so on, they are all medicine for treating skin disease, but different in uses. Vitamin A is the essential substance to maintain the body’s normal epithelial tissue function, if the body lacks of it, will cause dry skin, pilaris, conjunctival keratinization and other problems. Isotretinoin is a vitamin A derivatives, general used in ineffective treatment of severe acne cases, including those with adequate, enough course, systemic antibiotic treatment of invalid cases, or accompanied by severe nodule or cyst acne vulgaris, should first chose isotretinoin. At the beginning of therapy often combined with oral prednisone therapy, but prednisone can gradually stop in 3-4 weeks.

The recommended dose of isotretinoin is 0.5-2 mg per kg body weight daily oral, continuous use 16-20 week. On the general therapy of severe hidradenitis suppurativa, rosacea, acne, hair follicle keratinization of Gram-negative bacteria are effective. In addition, isotretinoin can stimulate collagen emerging, while the collagen is strong material to let the human skin young, the skin has more collagen fibers, it does not appear more wrinkles. The drug can also stimulate the growth of new blood vessels, let the skin look ruddy and health, so that make the dead cell shedding, grow fresh skin, therefore it also be made of adhesive, emulsion, cream for rhytidectomy.

However, taking isotretinoin should not used with vitamin A or tetracycline. The most serious side effect of isotretinoin is teratogenic, patients pregnancy after taking the drug, 1 / 3 of spontaneous abortion, 1 / 3 need induction of labor, another 1 / 3 has 20% of the fetuses appeared severe congenital malformation, therefore women in reproductive age need isotretinoin to treat should be first excluded pregnancy. The other side effects of isotretinoin has dry lips, cheilitis, dry mouth, dry skin, scaling, so taking the medicine should under the guidance of doctors, and pay attention to coat sunscreen. Tretinoin 0.1% cream

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